Cosmetic-grade Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan widely used in the cosmetic and skincare industries for its exceptional moisturizing, anti-aging, and skin-repairing properties. As a Contract Development and Manufacturing Organization (CDMO), we offer comprehensive solutions for the production of high-quality, cosmetic-grade hyaluronic acid to meet the diverse needs of our clients in the beauty and personal care sectors.

Cosmetic Grade Sodium Hyaluronate Products

The molecular weight distribution range of manufactured sodium hyaluronate is very wide, from 1KDa to 3000KDa. Sodium hyaluronate with different molecular weights has very different effects in cosmetics, and can be tailored according to customer needs.

HA Type	Molecular Weight Range	Function	Recommended Dosage	Main Uses
Oligomerized sodium hyaluronate	<10kDa	▪ Transdermal absorption	0.05%-0.5%	Cream, lotion, toner, gel, mask, essence, foundation, lipstick, eye shadow, shampoo, conditioner, hair gel, hair growth agent, facial cleanser, shower gel, etc.
Ultra low molecular weight sodium hyaluronate	<100kDa	▪ Transdermal absorption, deep moisturizing, repairing damaged cells	0.05%-0.5%
Low molecular weight sodium hyaluronate	100kDa-500kDa	▪ Deeply locking moisture, delivering nutrients, and moisturizing the dermis	0.05%-0.3%
Medium molecular weight sodium hyaluronate	500kDa-1500kDa	▪ Smooth, non-sticky, elastic, resistant to hyaluronidase degradation ▪ Form a mesh-like water film on the skin surface, long-lasting hydration, benefit for keratinocytes	0.05%-0.3%
High molecular weight sodium hyaluronate	1500kDa-2500kDa	▪ Excellent lubricity and film-forming properties, tightening skin and reducing water loss ▪ Thickening and stable emulsification	0.05%-0.1%

Our Advantages

Custom Formulation and Production

We work closely with our clients to develop customized hyaluronic acid formulations tailored to specific skincare products, including serums, moisturizers, masks, and injectables. Whether you're looking for high-molecular-weight HA for intense hydration or low-molecular-weight HA for deeper skin penetration, we can scale production to meet your needs.

Molecular Weight Range:

From low to high molecular weight HA, we provide a wide range of molecular sizes to cater to different skincare needs, from deep tissue hydration to surface-level moisture.

Customization:

We can modify the HA for enhanced stability, viscosity, or solubility depending on your product’s formulation requirements.

GMP-Compliant Manufacturing

Our manufacturing process adheres to Good Manufacturing Practice (GMP) guidelines, ensuring the highest quality standards and consistency in every batch. Our state-of-the-art production facilities are certified to meet international standards, including ISO 9001, and we follow stringent procedures to prevent contamination and ensure batch-to-batch consistency.

Full Regulatory Compliance:

We comply with all relevant global regulatory requirements, including those set by the FDA, EMA, and other cosmetic regulatory bodies.

Quality Assurance:

Extensive quality control processes, including testing for purity, molecular weight distribution, and endotoxin levels, ensure that every batch of HA meets the highest standards for cosmetic use.

Fermentation-Based Production

Our HA production process utilizes advanced fermentation technology, which offers a sustainable, efficient, and scalable method for producing high-quality hyaluronic acid. This biotechnological approach enables us to control the production process more precisely and efficiently than traditional animal-derived sources, ensuring purity and reducing the risk of contamination.

Sustainable and Ethical Production:

We use non-animal derived sources for HA production, making it suitable for vegan and cruelty-free product lines.

Scalability:

Our production systems are scalable from small batches for research and development to large-scale manufacturing for mass-market products.

High-Quality Purification

We employ advanced purification techniques to ensure that the hyaluronic acid is free from impurities, proteins, and endotoxins, providing a highly purified ingredient suitable for cosmetic formulations. Our purification process guarantees the highest levels of purity, safety, and efficacy, ensuring that your product meets both safety and quality standards.

Endotoxin Testing:

Our purification processes include endotoxin testing to ensure that the HA is safe for use in cosmetics and skincare products.

Purity and Consistency:

We maintain strict controls over the purification process to deliver a consistent and high-purity product every time.

Flexible Packaging and Delivery

We offer flexible packaging options, from small-scale R&D quantities to large-scale commercial packaging. Whether you need HA in bulk or packaged for end-use applications, we can accommodate various packaging sizes and formats to meet your production needs.

Bulk and Custom Packaging:

Available in multiple forms, including powder and liquid, with the option for custom packaging solutions based on client requirements.

Global Distribution:

We have the infrastructure to deliver HA products globally, ensuring a smooth and timely supply chain.

Customer Reviews

We’ve partnered with Creative Biogene for over two years now, and their expertise in cosmetic ingredient manufacturing has been invaluable to our product line. I can confidently say that their quality control and custom formulation capabilities have helped us develop some of our most successful skincare products.

-James Anderson

Process Development Specialist

The team at Creative Biogene is always responsive and proactive in meeting our unique needs, ensuring that our formulations are not only effective but also meet all regulatory requirements. Their ability to scale up production without compromising on quality has allowed us to grow confidently while maintaining the integrity of our products.

-Sophia Matthews

Founder & CEO

-James Anderson

Process Development Specialist

-Sophia Matthews

Founder & CEO