Cristispira Cultivation

The cells of Cristispira are single, curved, helically curved or planar corrugated cells 0.5-3.0μm in diameter. The total length of the screw is more than 80 microns, and it can be as long as 150 microns, and there are 2-10 complete curls. The ends of the cells are either rounded, tapered, or pointed. Its cells reproduce by transverse division.

The cells of Cristispira may contain 30-80 consecutive rows of oval inclusions of unknown composition, which replace the nuclear structure and cause the cells to streak horizontally on the stained slides. Normal motion can be moved forward and backward by means of a non-rotating, moving helical wave. The helix can also rotate or flex along its long axis. There are more than 100 axial filament wrapped around the protoplasmic cylinder, which can be seen with phase contrast microscopy when clustered in bundles. Degradation is prone to occur when removed from or disturbed its habitat conditions. The axial filament can leave the protoplast within the coating of the expanded helix, forming so-called ridges. In addition, it can also develop into central and terminal macrovesicles and helical cysts. After the structure is formed, the movement becomes irregular and the cells can be lysed.

Figure 1. Cristispira.Figure 1. Cristispira.

Cristispira is a symbiotic animal. It is widely distributed in the shells of two- and one-lobed mollusks in both marine and freshwater, and is usually found in crystalline tailpieces (a rod-like structure composed of mucus secretions) or in the fluids of the digestive tract. Also found in other animals, such as echinoderms and tunicates.

Cristispira Culture Service

Creative Biogene offers customizable Cristispira strain culture services. This service can help you obtain Cristispira cultures for subsequent scientific research. This service allows you to skip the complicated and tedious groping of culture conditions, which helps to speed up research on this strain.

Cristipira pectinis

Cristipira pectinis has cylindrical helical curved cells. The overall length of the helix is 36-72 microns, and the average width of the cells is 1.5 microns. Most Cristipira pectinis have four complete spirals. The ends are rounded or pointed, without apical appendages. There are 30-79 inclusion bodies in the cells, thus showing horizontal streaks and polar granules in the stained slides. Bend inwards before transversal splits. In fixed slices, ridges run along one side of the cell. Not easily seen on live specimens.

Cristipira pectinis are found in the stomach and intestines of scallops in the Gulf of Nabris (marine environment) and sometimes in their crystalline tail pieces.

Microbial GMP Production

Creative Biogene's fermentation platform has Good Manufacturing Practices (GMP) and can provide customers with a wide range of high-quality microbial fermentation products such as active pharmaceutical ingredients, enzymes and various fine chemicals. In addition, our microbiology experts have completed the transformation and innovation of traditional processes through continuous breakthroughs in key technologies of microbial fermentation processes, and fully contributed to the smooth delivery of the project.

Production Capacity

Creative Biogene builds a world-class microbial fermentation technology platform, providing a variety of services from strain screening and optimization to fermentation production and product purification. We have many years of rich experience and provide good technical support for microbial GMP production.

Facility Display

As a leader in microbial production, Creative Biogene has comprehensive production process technology and high-volume manufacturing capabilities. Our goal is to help our customers develop streamlined and controlled manufacturing processes and to support customers throughout the entire product development process, from the R&D stage to market launch.

Device Example:

  • Fermentation, centrifugation and filtration upstream process equipment;
  • Fully automatic fermenters ranging in volume from 4,000L to 12,000L with a total capacity of over 100,000 liters;
  • From industrial-scale chromatography systems, membrane systems to larger-scale continuous centrifuges;
  • Recycling and Downstream Equipment;
  • Waste treatment equipment.

Why Choose Us?

The culture of Cristispira requires specific formulations of growth media for use in cloning, plasmid DNA preparation, and protein expression. Creative Biogene offers a selection of bacterial growth media and custom services for your specific application. If you are interested in our microbial anaerobic and aerobic culture platform, please contact us for more details.


  1. Bergey's Manual of Systematic Bacteriology Book Review Int. J. of Syst. Bact.1985, p. 212.
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