Cosmetic Grade Polyglutamic Acid (PGA) is a naturally derived amino acid polymer. Similar to hyaluronic acid and soluble collagen, PGA is an excellent hydrophilic humectant capable of forming a smooth, elastic film on the skin, thereby improving sensory perception, protecting the outer layers of the skin, and increasing the production of natural moisturizing factors.
Extracted through an advanced fermentation and purification process, our premium PGA offers multifaceted utility across diverse industries.
Cosmetic Grade PGA
Purity: ≥90%
Food Grade PGA
Purity: ≥85%
Pharmaceutical Grade PGA
Purity: ≥95%
Agricultural Grade PGA
Purity: ~80%
Industrial Grade PGA
Purity: ~85%
Specifically designed for skincare formulations, it excels in enhancing moisture retention, surpassing conventional hyaluronic acid in certain aspects. As an effective cosmetic ingredient, PGA significantly improves moisture binding, elevating its efficacy in various skincare products. This can be very beneficial for stubborn dry, coarse, and flaky skin. PGA offering various molecular weights, each serving distinct roles in skincare. With a molecular weight around 5k Da, PGA ensures easy skin penetration and absorption, while PGA with a low molecular weight effectively combats free radicals, repairs photoaging, and rejuvenates the skin. On the other hand, higher molecular weights (ranging from 700k to 1000k Da) enhance water retention, ensuring optimal skin moisturization. These varied molecular weights cater to specific skincare needs, providing multifaceted benefits. Cosmetic-grade PGA is most commonly in the 500 kDa – 1,000 kDa range.
| Molecular Weight | Range | Characteristics | Cosmetic Application |
|---|---|---|---|
| PGA-SLM | ＜10KDa | Lower molecular weight sodium polyglutamate, better skin penetration, natural moisturizing factors accumulation, hydration capacity enhancement, melanin synthesis inhibition, and skin whitening. | Lightweight serums, fast-absorbing gels |
| PGA-LM | 10-700 Kda | Low molecular weight, skin smoothing, natural moisturizing factors accumulation, water holding capacity enhancement. Synergize with HA, and improve skin elasticity and softness. | Serums, masks, essence |
| PGA-HM | ＞700KDa | Slightly lower than super-high molecular weight, better film-forming moisturizing and thicken properties. | Moisturizers, sheet masks, barrier creams |
| PGA-SHM | ~2000KDa | Molecular weight up to 2 million Daltons, long-lasting moisturizing film on the skin surface, resisting damage from external pollutants. | Occlusive creams, sleeping masks |
Microbial production of cosmetic-grade PGA involves common or engineered microorganisms, typically Bacillus subtilis and Bacillus licheniformis, to express higher yields or enantiopurity (e.g. L-PGA vs DL-PGA), which are Non-pathogenic and GRAS (Generally Recognized as Safe). CRISPR/Cas or traditional mutagenesis strategies are utilized to boost PGA synthase (pgsBCA operon) expression and reduce degradation (deletion of pgdS).
| Fermentation Medium | Fermentation Conditions | Downstream Processing | |
|---|---|---|---|
| Parameter | Typical Range | ||
| Carbon source: Glucose, glycerol, or molasses | Temperature | 30–37°C | Cell Removal Centrifugation or filtration to separate cells from the culture supernatant |
| Minerals: Mn²⁺, Mg²⁺, Ca²⁺ (often essential for PGA synthesis) | pH | 6.5–7.2 (controlled automatically) | PGA Precipitation Add ethanol or isopropanol (1:1 or 1:2 ratio) PGA precipitates as a gel or fibrous mass |
| pH: Maintain at 6.5–7.5 (acidic conditions inhibit yield) | Aeration rate | ≥1 vvm (volume air/volume medium/minute) | Washing With alcohol or water to remove impurities (e.g., proteins, residual sugars) |
| Aeration: High oxygen demand → controlled via agitation and sparging | Time | 48–72 hours (batch) | Purification Optional ultrafiltration or dialysis (to improve cosmetic-grade purity) Activated carbon treatment if color reduction is required |
| Yield | ~20–80 g/L (can go higher in optimized fed-batch) | Drying Spray-drying or lyophilization (freeze-drying) for powder form |
|
| Cat # | Product Name |
|---|---|
| MFTP-044 | Polyglutamic Acid |
| MCLX0121 | Polyglutamic acid |
| Parameter | Goal |
|---|---|
| Purity (PGA) | ≥90% (cosmetic grade), ≥95% (premium) |
| Microbial count | <100 CFU/g (no pathogens) |
| Heavy metals | <10 ppm |
| Endotoxins | Low (non-sterile, but safe for topical use) |
| Molecular weight | Controlled via fermentation time and strain (e.g., 500 kDa – 2 MDa) |
We provide in vitro human skin tissue models for cosmetic testing services. Our models are very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.
In vitro Testing
Ex Vivo Skin Model Studies
Our manufacturing process adheres to Good Manufacturing Practice (GMP) guidelines, ensuring the highest quality standards and consistency in every batch. Our state-of-the-art production facilities are certified to meet international standards, including ISO 9001, and we follow stringent procedures to prevent contamination and ensure batch-to-batch consistency.
Full Regulatory Compliance:
We comply with all relevant global regulatory requirements, including those set by the FDA, EMA, and other cosmetic regulatory bodies.
Quality Assurance:
Extensive quality control processes, including testing for purity, molecular weight distribution, and endotoxin levels, ensure that every batch of HA meets the highest standards for cosmetic use.
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