Oral Microecology

Oral microbes

The complex structure, mild physical and chemical properties, appropriate temperature, humidity and rich nutrient sources of the oral provide a very suitable environment for the settlement, growth and reproduction of more than 700 kinds of microorganisms. Oral microorganisms include not only bacteria, but also fungi, viruses, spirochetes and archaea.

Under normal circumstances, close and complex interactions between oral microbial communities, and between microbes and hosts maintain the health of the host. Disruption of this ecological balance will cause diseases. Major oral diseases such as caries, periodontal disease, bacteremia and oral cancer seriously affect life and health. Among them, caries is closely related to Streptococcus mutans, and the culprit of chronic periodontitis is Porphyromonas gingivalis, however, their harm is far beyond the oral. For example, periodontitis can easily cause diabetes, cardiovascular disease, premature delivery as well as other major systemic diseases.

Research Direction

The main research directions of oral microbes including,

  • Study the oral microbial flora at different stages of growth and development.
  • Search for the difference in oral flora between the disease group and the healthy group.
  • Explore the relationship between oral microbes and oral health.
  • Identify drug targets for oral diseases.

Technical Process

  • The process of oral microbe high-throughput sequencing analysis.

The process of oral microbe high-throughput sequencing analysis - Creative Biogene

  • The process of oral microbe PCR-DEEG analysis.

The process of oral microbe PCR-DEEG analysis - Creative Biogene

Sample Type and Detection Type

  • The sample types are saliva and respiratory secretions. Recommend to use our product - microbial sample collection.
  • The requirements of DNA sample: total DNA ≥ 500ng, DNA concentration ≥ 10ng/μL, OD260/280 = 1.8 - 2.0.
  • The main detection types are oral bacteria and fungi.

What Can We Offer?

Based on 16S rDNA/18S rDNA genes, optimize experimental methods, use high-throughput sequencing technology to analyze the diversity of oral microbes, obtain accurate analysis of community structure, and phylogenetic relationships, then increase people's understanding of oral health and disease-related microbes.

The specific service content includes the following aspects, microbial isolation & cultivation, microbial identification, microbial sequencing, microbial proteomics, microbial metabonomics and bioinformatics analysis.

Bioinformatics analysis

OTU clustering Taxonomic analysis Phylogenetic analysis Analysis based on OUT Gene function  analysis
OTU distribution
Rarefaction curve
Shannon index curve
Rank abundance curve
Diversity index
Community composition analysis
Community correlation analysis
Community difference analysis
  • NMDS analysis
  • PCA
  • PCoA
  • LEfSe differential analysis
  • Network diagram
UniFrac analysis
Phylogenetic tree
OTU correlation analysis
  • Heatmap
  • Venn diagram
KEGG analysis
GO analysis
MetaCyc analysis
EggNOG analysis
CAZy analysis
CARD analysis

Our Advantages 

  • Our professional researchers have rich experience in oral microecology.
  • We provide a full range of oral microecology solutions to meet your various needs.
  • High quality, quick turnaround time and affordable cost.
  • We will feedback progress to customers in time to ensure that your requirements are met.

Oral is the link between the human body and the external environment, and the oral microbial community is closely related to human health. Creative Biogene's skilled microbiologists have extensive experience of providing GMP standard services to the oral microecology. Combining rich project experience, strict data quality control and professional analysis process, we will ensure that the project is carried out accurately and quickly.

If you are interested in our services, please contact us for more details.


  1. Zhang J, et al. (2010). "A preliminary study of biological characteristics of Streptococcus oligofermentans in oral microecology." Caries research. 44.4: 345-348.
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