The complex structure, mild physical and chemical properties, appropriate temperature, humidity and rich nutrient sources of the oral provide a very suitable environment for the settlement, growth and reproduction of more than 700 kinds of microorganisms. Oral microorganisms include not only bacteria, but also fungi, viruses, spirochetes and archaea.
Under normal circumstances, close and complex interactions between oral microbial communities, and between microbes and hosts maintain the health of the host. Disruption of this ecological balance will cause diseases. Major oral diseases such as caries, periodontal disease, bacteremia and oral cancer seriously affect life and health. Among them, caries is closely related to Streptococcus mutans, and the culprit of chronic periodontitis is Porphyromonas gingivalis, however, their harm is far beyond the oral. For example, periodontitis can easily cause diabetes, cardiovascular disease, premature delivery as well as other major systemic diseases.
The main research directions of oral microbes including,
Based on 16S rDNA/18S rDNA genes, optimize experimental methods, use high-throughput sequencing technology to analyze the diversity of oral microbes, obtain accurate analysis of community structure, and phylogenetic relationships, then increase people's understanding of oral health and disease-related microbes.
The specific service content includes the following aspects, microbial isolation & cultivation, microbial identification, microbial sequencing, microbial proteomics, microbial metabonomics and bioinformatics analysis.
|OTU clustering||Taxonomic analysis||Phylogenetic analysis||Analysis based on OUT||Gene function analysis|
Shannon index curve
Rank abundance curve
|Community composition analysis
Community correlation analysis
Community difference analysis
|OTU correlation analysis
Oral is the link between the human body and the external environment, and the oral microbial community is closely related to human health. Creative Biogene's skilled microbiologists have extensive experience of providing GMP standard services to the oral microecology. Combining rich project experience, strict data quality control and professional analysis process, we will ensure that the project is carried out accurately and quickly.
If you are interested in our services, please contact us for more details.