EggNOG Analysis

EggNOG (Evolutionary Genealogy of Genes: Non-supervised Orthologous Groups) database collects 5,090 organisms (477 eukaryotes, 4,445 representative bacteria and 168 archaea) and 2,502 viruses COG (Clusters of Orthologous Groups of proteins). Each COG is assumed to be from an ancestor, and each protein has an integrated and summarized functional annotation. EggNOG can provide COG at different classification levels, divide these species into 379 taxonomic levels, and the number of each category is represented by the NCBI classification number. EggNOG classified homologous genes for the COG of each species, and carries out multiple sequence alignment, phylogenetic tree construction, HMM file construction and functional annotation for each homologous gene category.

The EggNOG database is an extension of NCBI's COG database, and EggNOG collects more comprehensive species and a larger amount of protein sequence data. The cluster analysis of homologous genes and the description and function classification of each homologous gene class are also carried out.

Functional analyses on OGs of the gut microbiota. Summary of unigenes matched to each EggNOG functional categories present in the gut metagenome datasetsFig.1 Functional analyses on OGs of the gut microbiota. Summary of unigenes matched to each EggNOG functional categories present in the gut metagenome datasets. (Wang T, et al. 2020)

Service Offering

Our services in EggNOG analysis include,

  • Construction of phylogenetic tree
  • Functional annotation for homologous gene category
  • Other customized services you require

Turnaround Time

In general, our turnaround time is 2-4 weeks depending on the size of your project.

Advantages of Our Services 

  • We have rich experience in bioinformatics analysis, especially in EggNOG analysis.
  • We will customize the analysis items according to your requirements, and offer you a one-stop service.
  • We provide fast turnaround, high quality analysis reports at competitive prices to our global customers.
  • We will feedback progress to customers in time to ensure that your requirements are met.

Creative Biogene is a forward-looking research institution in the field of EggNOG analysis. Our advanced analysis platforms are established to provide you with results of good reproducibility. EggNOG database categorizes more comprehensive species and a larger number of protein sequences, enabling the analysis results more accurate. We will uphold the belief of pursuing high quality and the spirit of professionalism and dedication to provide you with our optimal service.

If you are interested in our services, please contact us for more details.


  1. Wang T, et al. (2020). "A comparative study of microbial community and functions of type 2 diabetes mellitus patients with obesity and healthy people." Applied Microbiology and Biotechnology. 104.16: 7143-7153.
  2. Huerta C, et al. (2016). "EggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences." Nucleic acids research. 44.D1: D286-D293.
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