Microbial Production of Biomass

Microbial fermentation offers advantages in biomass production, such as rapid growth rates, scalability, and the ability to utilize diverse carbon sources. Additionally, the fermentation process can be optimized to enhance the yield and quality of the biomass or specific products derived from it. Microbial biomass can be further processed to extract specific components or convert it into other forms, such as biofuels, bioplastics, or biochemicals.

Microbial Industrial Fermentation at Creative Biogene

  • Strain development and improvement through genetic engineering and metabolic engineering
  • Sterile and advanced facility for cell bank preparation and storage
  • Scale-down and scale-up process development
  • Fermenters with a wide range of volumes from 1,000 liters to 10,000 liters
  • Downstream processing development and computerized records

Microbial Production of Biomass

Custom Options for Microbial Biomass Production


Microbial Biomass Applications

Agriculture Industry

Soil quality is directly affected by alterations in its microbiological, biological, biochemical, physical, and chemical aspects. The microbiological activities of soil can affect soil fertility and plant growth. The diversity and biomass of soil microbial communities are the major regulators of fundamental ecosystem processes, such as organic matter decomposition, nutrient (e.g., enzymes and hormones) cycling, and gaseous fluxes.

Microorganism Functions
Pseudomonas fragi,
Pseudomonas simiae,
Clostridium vincentii,
Pseudomonas jessenii,
Iodobacter fluviatilis
Contributed to composting startup at low temperature
Brevundimonas diminuta,
Flavobacterium glaciei,
Aspergillus niger,
Penicillium commune
Promotes maturity of dairy manure-rice straw composting under cold climate conditions
Pichia kudriavzevii Promote degradation of organic acid and accelerating the composting process
Phanerochaete chrysosporium Stabilize in composting of lead contaminated agricultural waste

Table 1. Examples of microbial biomass used for composting

Food and Feed Industry

Edible microbial biomass derived from bacteria, yeasts, filamentous fungi or microalgae is a promising alternative to conventional sources of food and feed. Microorganisms are a good source of protein, vitamins and, in some cases, also contain beneficial lipids. The ability of microorganisms to use simple organic substrates for growth permits industrial-scale cultivation of edible microbial biomass.

Food and Feed Products Sources Type
Methylocccus capsulatus Bacterium
Methylobacterium extorquens Bacterium
Pichia pastoris Yeast
Methylophilus methylotrophus Bacterium
Fusariumn venenatum Filamentous fungus
Artrospira sp. Cyanobacterium
Methylococcus capsulatus Bacterium

Table 2. Examples of food and feed products based on microbial biomass

Waste Management

Cellular biomass of microorganisms can be effectively used in the treatment of waste from various branches of the agro-food industry. Microbial biomass offers an economical option for removing heavy metals from wastes by the phenomenon of biosorption. Further biosorption potential of the biomass can be improved by various physical and chemical treatments.

Biosorbent Examples/species
Algae Fucus, Chlamydomonas, Cladophora, Spirogyra sp.
Bacteria Bacillus sp., Vibrio sp., Geobactor sp., Pseudomonas sp., Desulfovibrio sp.
Fungi Pleurotus sp., Aspergillus sp., Penicillium sp., Rhizopus sp., Saccharomyces sp.

Table 3. Examples of microorganisms as biosorbents

Bioenergy Industry

The consumption of organic substrates by a microorganism and its further utilization in the metabolic processes generates useful products, which can be used as a fuel to produce energy. The metabolic diversity of different microorganisms enables the production of biofuels from various substrates.

Microorganism Biofuel
Clostridium acetobutylicum Butanol
Clostridium thermocellum lsobutanol
Escherichia coli Butanol
Escherichia coli Ethanol
Saccharomyces cerevisiae Fatty acids
Saccharomyces cerevisiae lsoprenoid based-biofuel
Pseudomonas putida Butanol
Cryptococcus vishniacci Lipids
Zymomonas mobilis 2, 3-butanediol
Zymomonas mobilis Ethanol
Caldicellulosiruptor bescii Ethanol
Trichoderma reesei Ethanol
Yarrowia lipolytica Fatty acids
Synecococcus sp. Limonene
Synecococcus elongates 1, 3-propanediol

Table 4. List of microorganisms for biofuels production

Creative Biogene offers CDMO services for various microbial biomass. We have the commercial experience and technological flexibility to scale manufacturing on a need-based or rolling basis. Our sites are growing globally as the expansion of facilities has increased the capacity for microbial systems.

If you are interested in our services, please contact us for more details.

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