Neurotransmitters are chemicals that transmit messages between neurons or between neurons and effector cells, act as "messengers" throughout the process. According to the chemical composition characteristics of neurotransmitters, there are mainly cholines, monoamines, amino acids and neuropeptides, etc. Currently, neurotransmitters that have been identified include dopamine, norepinephrine, acetylcholine, serotonin and so on.
In the process of neuron information transmission, when a neuron is stimulated by signals from the environment or other neurons, the transmitters stored in the presynaptic vesicles can be released to the synaptic cleft and act on the postsynaptic membrane and transmitting transmitter signals to the next neuron. Neurotransmitters mainly transmit signals in paracrine mode, so they are fast and accurate. The termination of the transmitter signal can depend on the decomposition and destruction of the corresponding hydrolase on the synaptic cleft or posterior membrane, or the body weight uptake by the presynaptic membrane-specific transporter.
In recent years, neurotransmitters have become the subject of intensive research. For instance, acetylcholine has been widely studied due to its effect on alertness, memory and learning, which are essential neurotransmitters in the central nervous system. In addition, the detection of neurotransmitters also plays a very important role in the study of epilepsy, Parkinson's disease, metabolic diseases and tumors.
Creative Biogene's neurotransmitter detection service provides results including,
Our bioinformatics analysis covers a wide range including transition pair selection, standard curve drawing, data quality control, quantitative results of target small molecules, comparative group analysis and phenotypic analysis, etc.
Acetylcholine, catecholamine, serotonin, γ-aminobutyric acid and histamine.
Instrument platform: LC-MS-MS and MRM.
In general, our turnaround time is 3-5 weeks depending on the size of your project.
Creative Biogene has excellent microbiology experts, well-established metabolome detection platforms, and professional bioinformatics analysis to provide you with a one-stop service in neurotransmitter detection. Our services include sample collection, metabolite extraction, pre-processing, detection and analysis.
If you are interested in our services, please contact us for more details.