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NMR Detection

NMR

Nuclear Magnetic Resonance (NMR) is a physical process in which atomic nuclei with non-zero magnetic moments, undergoes Zeeman splitting of the spin energy level under the action of an external magnetic field, and resonantly absorbs radiofrequency radiation of a certain frequency. NMR spectroscopy technology has always been the main analysis technology for the structural information of organic compounds and biomolecules, because in many cases, it can provide valuable structural information of the entire molecule through a set of analysis tests.

NMR spectrum analysis ranges from small organic molecules or metabolites to medium-sized peptides or natural products, then to biological macromolecules and high molecular weight synthetic polymers. As a powerful analysis platform, NMR spectroscopy can replace other technologies (such as X-ray, crystallography and mass spectrometry) to obtain structural information. NMR spectroscopy can perform non-destructive, qualitative and quantitative researches on solutions and solid molecules.

Application of NMR Detection

NMR spectroscopy technology has developed at an astonishing speed and has become an indispensable analytical tool in the field of cutting-edge scientific and technological fields including biology, food, chemistry, and battery films. NMR spectroscopy is also suitable for metabolite analysis, because it can simultaneously detect a variety of different primary metabolites (sugars, organic acids, amino acids, etc.) and secondary metabolites (flavonoids, alkaloids, triterpenes, etc.). Through statistical analysis by principal component analysis (PCA), it is possible to evaluate patterns related to changes in the levels of individual metabolites in several samples.

Our Service Process

The service process of NMR detection - Creative Biogene

Service Offering

Creative Biogene’s NMR detection service provides results including,

  • Raw data
  • Experimental steps
  • Related mass spectrometry parameters
  • Quantitative or qualitative information of the identified substance
  • Mass spectrum picture
  • Bioinformatics analysis report

Our bioinformatics analysis covers a wide range including data quality control, variables analysis, differential ion screening and identification, cluster detection, metabolite correlation analysis, and other personalized analysis.

Sample Type

Feces, blood, urine, cells, plant extract and microbes, etc.

Detection platform

Instrument platform: NMR.

Turnaround Time

In general, our turnaround time is 3-5 weeks depending on the size of your project.

Advantages of Our Services 

  • Our advanced NMR detection platforms allow us to detect more metabolite information.
  • We have a professional team of experts who can conduct personalized bioinformatics analysis according to your needs.
  • We have a high-quality database, and the accuracy of metabolite detection is high.
  • The experiment operation is carried out in strict accordance with SOP standards, and multiple quality controls ensure that the authenticity and reliability of the experimental results.

Creative Biogene has excellent microbiology experts, well-established metabolome detection platforms, and professional bioinformatics analysis to provide you with a one-stop service in NMR detection. Our services include sample collection, pre-processing, detection and analysis.

If you are interested in our services, please contact us for more details.

Reference

  1. Garcia I, et al. (2020) "Identifying unknown metabolites using NMR-based metabolic profiling techniques." Nature Protocols.15, 2538-2567.
For Research Use Only.

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