Staphylococcus aureus is a representative of gram-positive bacteria and widely exists in the natural environment. Staphylococcus aureus is a common food-borne pathogenic microbe. Under appropriate conditions, it can produce enterotoxins and cause food poisoning. It is associated with high morbidity and mortality due to its obvious pathogenicity and multidrug resistance. In many countries, the emergence of antibiotic-resistant strains, such as methicillin-resistant and vancomycin-resistant Staphylococcus aureus, has rendered the bacteria as the cause of the infectious diseases with the highest mortality rate， emphasizing a dire need for novel drug-target exploration and drug development.
Creative Biogene has developed a fast and accurate CRISPR/cas9-mediated genome editing technology for Staphylococcus aureus. This technology combines the use of recombination to achieve efficient genome editing of Staphylococcus aureus, including gene deletion, single-base substitution mutation and gene insertion, making it possible to scalably and inexpensively engineer desired changes.
Staphylococcus aureus genome editing will contribute to the search for solving various problems related to the function of specific genes and specific mutations. The development of new genome editing and screening tools will greatly facilitate the acquisition of unexplored drug targets, which will enable the effective discovery and verification of unidentified genes and pathways that lead to bacterial toxicity and drug resistance.
Creative Biogene uses two methods to achieve Staphylococcus aureus genome editing, they are,
The specific content of the Staphylococcus aureus genome editing service provided by Creative Biogene includes,
In general, our turnaround time is 4-8 weeks depending on the size of your project.
Creative Biogene has excellent microbiology experts, well-established gene editing platforms, and professional bioinformatics analysis to provide you with a one-stop service in Staphylococcus aureus genome editing. We believe that our services will make your project more effective.
If you are interested in our services, please contact us for more details.