Cosmetic-grade Collagen

Collagen is a structural protein composed of amino acids that create collagen fibers, characterized by exceptional strength and high elasticity. This protein is composed of three left-handed α polypeptides that wind around themselves and their axis to form a right-handed superhelix. The most important types of collagen found in the skin are type I and type III. Cosmetic grade collagen product is specifically processed and formulated for its moisturizing, anti-aging, and skin-repairing properties, used as ingredients in various cosmetic products, such as gels, creams, beauty masks, and serums.

Collagen Products Options

You can choose desired collagen products for your particular use.

Cosmetic Grade Collagen

Food Grade Collagen

Pharmaceutical Grade Collagen

Research Grade Collagen

Cosmetic Grade Collagen Products Options

Cosmetic grade collagen is used in a range of applications, and its molecular weight (MW) plays a critical role in determining its function, skin absorption, and formulation behavior. You can choose desired collagen products for particular use.

Type	Molecular Weight Range	Description	Key Benefit	Typical Applications
Native (Intact) Collagen	~300–400 kDa	Triple-helix structure (Type I, II, III); high MW; poor skin penetration	Moisture barrier, firming	Film-forming, hydration barrier, anti-wrinkle creams
Hydrolyzed Collagen (Collagen Peptides)	~1–10 kDa (often ~3–6 kDa)	Enzymatically or chemically broken down; small peptides	Hydration, bioavailability	Absorbable serums, anti-aging creams, oral supplements
Oligopeptides / Collagen Fragments	<1 kDa	Short bioactive peptides derived from collagen	Signal skin regeneration	Bio-signaling molecules, booster serums, premium skincare
Recombinant Collagen / Engineered Collagen-like Proteins	Variable (5–100+ kDa)	Designed for functionality; may not replicate full MW of native collagen	Ethical, tailored properties	Vegan/ethical products, medical-cosmetic hybrids

Optimized Production Platform

Produced through our high-density fermentation process using microbial hosts, the final product is pure and completely animal free. We have a range of products available including raw materials, finished forms and OEM services.

Request a Custom Production

Collagen Production

Microbial production of cosmetic-grade collagen is an innovative and sustainable alternative to traditional animal-derived sources. It involves engineering microorganisms (typically E. coli, Pichia pastoris, Saccharomyces cerevisiae, or Bacillus subtilis) to express recombinant collagen or collagen-like proteins, which are then purified and formulated for cosmetic applications.

	Expression System	Transduced Gene	Expressed Collagen	Descriptions
Prokaryote	Escherichia coli	COL1A1	Type I	Different amino acid expression when compared to natural collagen
Prokaryote	Escherichia coli	COL3A1; L230, L593 (APMV)	Type III	Expression collagen III and mimivirus propyl and lysyl hydroxylases yielded hydroxylation levels similar to those expressed in humans
Yeast	Pichia pastoris	COL1A1, PH4A/B	Type I	-
	Pichia pastoris	COL3A1, PH4A/B	Type III	Recombinant hydroxylated collagen III exhibited hemostatic properties in vivo
	Saccharomyces cerevisiae	COL3A1, PH4A/B	Type III	Computational algorithm determined optimal oligonucleotide sequence
	Saccharomyces cerevisiae	COL3A1, PH4A/B	Type III	Addition of non-native cysteine residues created crosslinking and anchoring sites; increased melting point compared to other RHC

Efficacy Evaluation

We provide in vitro human skin tissue models for cosmetic testing services. Our models are very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.

In vitro Testing

Hydration Capacity Assay
Skin Barrier Function Tests
Anti-Inflammatory & Antioxidant Tests

Ex Vivo Skin Model Studies

Use human skin explants to observe penetration and bioactivity.

Our Advantages

GMP-Compliant Manufacturing

Our manufacturing process adheres to Good Manufacturing Practice (GMP) guidelines, ensuring the highest quality standards and consistency in every batch. Our state-of-the-art production facilities are certified to meet international standards, including ISO 9001, and we follow stringent procedures to prevent contamination and ensure batch-to-batch consistency.

Full Regulatory Compliance:

We comply with all relevant global regulatory requirements, including those set by the FDA, EMA, and other cosmetic regulatory bodies.

Quality Assurance:

Extensive quality control processes, including testing for purity, molecular weight distribution, and endotoxin levels, ensure that every batch of HA meets the highest standards for cosmetic use.

Customer Reviews

Working with your team on microbial collagen development was a turning point for our clean beauty line. The purity, yield, and consistency of the collagen exceeded our expectations.

-Dr. Melissa Tran

R&D Director

We were looking for a vegan, high-performance collagen ingredient—and your recombinant process delivered. The support throughout tech transfer and scale-up was outstanding.

-Andrei Kovacs

Formulation Lead

Your cosmetic-grade collagen helped us launch our anti-aging serum with a sustainable edge. Our customers love the results—and the story behind the science.

-Julia Ramos

Head of Product Innovation

The hydrolyzed recombinant collagen you provided integrates seamlessly into our topical formulations. The low molecular weight variant improved absorption and stability.

-Lisa O’Connell

Skincare Technologist

Partner with Us

Whether you are looking for a reliable partner for small-scale R&D or large-scale commercial production of collagen, our Cosmetic-Grade collagen CDMO services provide the expertise, flexibility, and quality you need. From fermentation and purification to formulation and regulatory compliance, we are equipped to support every stage of your collagen production process, helping you deliver superior skincare products to your customers.