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Cosmetic-grade Collagen

Collagen is a structural protein composed of amino acids that create collagen fibers, characterized by exceptional strength and high elasticity. This protein is composed of three left-handed α polypeptides that wind around themselves and their axis to form a right-handed superhelix. The most important types of collagen found in the skin are type I and type III. Cosmetic grade collagen product is specifically processed and formulated for its moisturizing, anti-aging, and skin-repairing properties, used as ingredients in various cosmetic products, such as gels, creams, beauty masks, and serums.

Collagen Products Options

You can choose desired collagen products for your particular use.

Cosmetic Grade Collagen

Food Grade Collagen

Pharmaceutical Grade Collagen

Research Grade Collagen

Cosmetic Grade Collagen Products Options

Cosmetic grade collagen is used in a range of applications, and its molecular weight (MW) plays a critical role in determining its function, skin absorption, and formulation behavior. You can choose desired collagen products for particular use.

Type Molecular Weight Range Description Key Benefit Typical Applications
Native (Intact) Collagen ~300–400 kDa Triple-helix structure (Type I, II, III); high MW; poor skin penetration Moisture barrier, firming Film-forming, hydration barrier, anti-wrinkle creams
Hydrolyzed Collagen (Collagen Peptides) ~1–10 kDa (often ~3–6 kDa) Enzymatically or chemically broken down; small peptides Hydration, bioavailability Absorbable serums, anti-aging creams, oral supplements
Oligopeptides / Collagen Fragments <1 kDa Short bioactive peptides derived from collagen Signal skin regeneration Bio-signaling molecules, booster serums, premium skincare
Recombinant Collagen / Engineered Collagen-like Proteins Variable (5–100+ kDa) Designed for functionality; may not replicate full MW of native collagen Ethical, tailored properties Vegan/ethical products, medical-cosmetic hybrids

Optimized Production Platform

Produced through our high-density fermentation process using microbial hosts, the final product is pure and completely animal free. We have a range of products available including raw materials, finished forms and OEM services.

Collagen Production

Microbial production of cosmetic-grade collagen is an innovative and sustainable alternative to traditional animal-derived sources. It involves engineering microorganisms (typically E. coli, Pichia pastoris, Saccharomyces cerevisiae, or Bacillus subtilis) to express recombinant collagen or collagen-like proteins, which are then purified and formulated for cosmetic applications.

  Expression System Transduced Gene Expressed Collagen Descriptions
Prokaryote Escherichia coli COL1A1 Type I Different amino acid expression when compared to natural collagen
Escherichia coli COL3A1; L230, L593 (APMV) Type III Expression collagen III and mimivirus propyl and lysyl hydroxylases yielded hydroxylation levels similar to those expressed in humans
Yeast Pichia pastoris COL1A1, PH4A/B Type I -
Pichia pastoris COL3A1, PH4A/B Type III Recombinant hydroxylated collagen III exhibited hemostatic properties in vivo
Saccharomyces cerevisiae COL3A1, PH4A/B Type III Computational algorithm determined optimal oligonucleotide sequence
Addition of non-native cysteine residues created crosslinking and anchoring sites; increased melting point compared to other RHC
Agriculture Microbiology

Efficacy Evaluation

We provide in vitro human skin tissue models for cosmetic testing services. Our models are very similar to human skin in terms of morphology, of differentiation markers and of functional characteristics.

In vitro Testing

  • Hydration Capacity Assay
  • Skin Barrier Function Tests
  • Anti-Inflammatory & Antioxidant Tests

Ex Vivo Skin Model Studies

  • Use human skin explants to observe penetration and bioactivity.

Our Advantages

Customer Reviews

Partner with Us

Whether you are looking for a reliable partner for small-scale R&D or large-scale commercial production of collagen, our Cosmetic-Grade collagen CDMO services provide the expertise, flexibility, and quality you need. From fermentation and purification to formulation and regulatory compliance, we are equipped to support every stage of your collagen production process, helping you deliver superior skincare products to your customers.

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