Microbial CDMO Services

Creative Biogene is a biotech CDMO for bacterial and yeast-based production of Drug Substances. Our microbial production services include GMP production of recombinant proteins, plasmid DNA, single-domain antibodies, recombinant vaccines, nucleic acid drugs, etc. Our microbial GMP-manufacturing unit is equipped with state-of-the-art fermenters, harvesting equipment, and a choice of downstream purification capabilities. Manufacturing and purification options cover both secreted and intracellular products.

Service Capabilities

Cell Banks Generation (RCB, MCB / WCB)

Upstream Processes

• Stirred Tank bioreactors
• Bacteria and yeasts fermentation
• Target protein expression
• Tangential flow filtration or continuous centrifugation
• Cell homogenization
• Enzymatic treatment
• Harvest clarification (TFF, continuous centrifugation or deep filtration)

Downstream Processes

• Protein denaturation/Refolding
• Chromatographic purification (AIEX, CIEX, Multimodal, SEC, Column and membrane chromatography)
• Tangential Flow Filtration

Quality Assurance and Quality Control

• Microbiological product-specific assays
• Analytical Services and Safety Assays (sterility, Bioburden, and Endotoxin, etc)
• Compendial analyses and full GMP documentation

Advances in synthetic biology and a shift towards sustainable manufacturing methods are helping to drive demand for the selection of CDMOs with best-in-class microbial fermentation capabilities. Creative Biogene has served as a reliable fermentation partner to pharmaceutical companies. We have leveraged our expertise across fermentation and biocatalysis technologies including strain development, process optimization and large-scale manufacturing. We are ready to support your upcoming projects regardless of scale or complexity.

If you are interested in our services, please contact us for more details.