Caulococcus Cultivation

Caulococcus has spherical cells approximately 0.5 microns in diameter. They can be connected by filaments of about 0.1 microns in diameter. In the accumulation of bacterial micelles, reproduction occurs in the form of budding. Young cells can move. Microcolonies are up to 0.3 mm thick and have a surface structure of reticulate protrusions. Its shape is irregular or round. Some are nearly black radiating lobed (rare) or hairy bulbs (rare). The edges of the microcolonies often have radial streaks composed of bifurcated filamentous cells. Spherical cells are fewer in radial split-leaf colonies and more in round, densely shelled colonies.

Figure1. SEM photo of iron oxide fiber biomineralized by iron bacteria. (Deyuan Zhang, et al.; 2022)Figure1. SEM photo of iron oxide fiber biomineralized by iron bacteria. (Deyuan Zhang, et al.; 2022)

Caulococcus is microaerobic. Its precipitates are mainly Mn3+ (80-90%) and some Fe3+ (20-10%). The bacteria can be transferred with a sample of mud and then observed by microcapillary technique.

Originally found in large quantities in Khepo-yarvi Lake, especially in mineral deposits; often observed in upper reducing formations, in the upper layers of sediment deposits, or in bottom water covering the mud surface. In addition, Caulococcus has also been observed in some other lakes in these regions.

Caulococcus Culture Service

Creative Biogene offers customizable Caulococcus strain culture services. This service can help you obtain Caulococcus cultures for subsequent scientific research. This service allows you to skip the complicated and tedious groping of culture conditions, which helps to speed up research on this strain.

Caulococcus manganifer

The morphology of Caulococcus manganifer is the same as the described genus.

Microbial GMP Production

Creative Biogene's fermentation platform has Good Manufacturing Practices (GMP) and can provide customers with a wide range of high-quality microbial fermentation products such as active pharmaceutical ingredients, enzymes and various fine chemicals. In addition, our microbiology experts have completed the transformation and innovation of traditional processes through continuous breakthroughs in key technologies of microbial fermentation processes, and fully contributed to the smooth delivery of the project.

Production Capacity

Creative Biogene builds a world-class microbial fermentation technology platform, providing a variety of services from strain screening and optimization to fermentation production and product purification. We have many years of rich experience and provide good technical support for microbial GMP production.

Facility Display

As a leader in microbial production, Creative Biogene has comprehensive production process technology and high-volume manufacturing capabilities. Our goal is to help our customers develop streamlined and controlled manufacturing processes and to support customers throughout the entire product development process, from the R&D stage to market launch.

Device Example:

  • Fermentation, centrifugation and filtration upstream process equipment;
  • Fully automatic fermenters ranging in volume from 4,000L to 12,000L with a total capacity of over 100,000 liters;
  • From industrial-scale chromatography systems, membrane systems to larger-scale continuous centrifuges;
  • Recycling and Downstream Equipment;
  • Waste treatment equipment.

Why Choose Us?

The culture of Caulococcus requires specific formulations of growth media for use in cloning, plasmid DNA preparation, and protein expression. Creative Biogene offers a selection of bacterial growth media and custom services for your specific application. If you are interested in our microbial anaerobic and aerobic culture platform, please contact us for more details.


  1. Bergey's Manual of Systematic Bacteriology Book Review Int. J. of Syst. Bact.1985, p. 204.
  2. Deyuan Zhang, et al.; Transport and deposition structure of cell nano interface. Natural mineralization. Elsevier. 2022, ISBN:978-0-12-824502-6.
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