Skin Microecology

Skin microbes

As the largest organ of the human body, the skin has a surface area of 1.8 m2, and its main function is to act as a physical barrier to protect the body from foreign organisms or toxic substances. Meanwhile, the skin is also where the body comes into contact with the external environment, so there are various types of microbes that are resident here. Skin microecology refers to an ecosystem composed of bacteria, fungi, viruses, mites and other microbes together with skin surface tissues, cells, various secretions, and microenvironment.

The interaction of skin microbes, hosts and external environment constitutes the skin microecological balance, forming the first biological barrier on the skin surface. Once this balance is broken, it may cause skin diseases or infections. Changes in skin microecology are related to the occurrence and development of various inflammatory and infectious diseases such as psoriasis, atopic dermatitis, acne and chronic wounds. Common skin surface flora includes Propionibacterium, Corynebacterium, Staphylococcus aureus, etc.

Research Direction

The main research directions of skin microbes including,

  • Compare the differences in microbial flora between healthy skin and diseased skin.
  • Explore the skin microbes in the development of a skin disease
  • Study the skin microbes of different body parts of the same individual.
  • Study the skin microbes of drug intervention groups.
  • Identify drug targets for skin microorganisms.

Technical Process

  • The process of skin microbe high-throughput sequencing analysis.

The process of skin microbe high-throughput sequencing analysis - Creative Biogene

  • The process of skin microbe PCR-DEEG analysis.

The process of skin microbe PCR-DEEG analysis - Creative Biogene

Sample Type and Detection Type

  • The sample types are skin epidermis and subcutaneous tissue. Recommend to collect samples according to relevant literature, and use our product - microbial sample collection.
  • The main detection types are bacteria, fungi, viruses, etc.

What Can We Offer?

  • Cultivation, isolation and identification of skin microbes.
  • Gene editing of skin microbes.
  • Study the function and diversity of skin microbes.
  • Explore the relationship between skin microbes and the environment.

The specific service content includes the following aspects, microbial isolation & cultivation, microbial identification, microbial sequencing, microbial proteomics, microbial metabonomics, microbial genome editing and bioinformatics analysis.

Bioinformatics analysis

OTU clustering Taxonomic analysis Phylogenetic analysis Analysis based on OUT Gene function  analysis
OTU distribution
Rarefaction curve
Shannon index curve
Rank abundance curve
Diversity index
Community composition analysis
Community correlation analysis
Community difference analysis
  • NMDS analysis
  • PCA
  • PCoA
  • LEfSe differential analysis
  • Network diagram
UniFrac analysis
Phylogenetic tree
OTU correlation analysis
  • Heatmap
  • Venn diagram
KEGG analysis
GO analysis
MetaCyc analysis
EggNOG analysis
CAZy analysis
CARD analysis

Our Advantages 

  • We have a professional team of experts who can conduct personalized skin microecology analysis.
  • We provide fast turnaround, high quality analysis reports at competitive prices.
  • We have a well-established quality management system to ensure the quality of our services.

Skin health should not be neglected. If the skin microecological balance is broken, it may destroy the skin barrier and lead to the adverse development of the immune system, thus causing skin and even systemic diseases. Creative Biogene provides a complete solution for your skin microecology research, and invites you to enjoy a one-step service experience. It is sincerely looking forward to cooperating with you.

If you are interested in our services, please contact us for more details.

For Research Use Only.
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