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Recombinant Phosphodiesterase 5A1 from Human

 Product Information

Cat #
MBS-0784
CAS No.
Enzyme Commission Number
EC 3.1.4.53
Product Overview
High-quality enzyme products. Well-defined strains can be also provided for our clients to manufacture fermented products in a cost-effective way.
Features
Ready-to-use product, accelerating research progress, enhancing application performance.
Method
Technology
Synonyms
cAMP-specific phosphodiesterase; cAMP-specific PDE; PDE1; PDE2A; PDE2B; PDE4; PDE7; PDE8; PDEB1; PDEB2
Type
Function
Requires Mg2+ or Mn2+ for activity. This enzyme is specific for 3′,5′-cAMP and does not hydrolyse other nucleoside 3′,5′-cyclic phosphates such as cGMP (cf. EC 3.1.4.17, 3,5-cyclic-nucleotide phosphodiesterase and EC 3.1.4.35, 3,5-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
Applications
Research Use
Storage
−70°C
Storage Buffer
Shelf Life
Strains
Sf9 cells
Source
Sf9 cells
Appearance
Molecular Weight
126 kDa
Color / Form
Instruction
Enzyme Class
Hydrolases
Production Methods
Fermentation
Activity
Specific Enzyme Activity
Purity
Unit Definition
One unit will convert 1.0 picomole of 3',5'-cGMP to 5'-GMP per minute at pH 7.4 at 37°C.
Amino Acids Sequence
WARNINGS
Shipping
Formula
Reaction
adenosine 3′,5′-cyclic phosphate + H2O = AMP
Recommendation
Species Reactivity
Contents
Compatibility
Melting Point
Final Titre
Fermentation Time
Recovery Yield
Starting Material
Specification
On customer requests
Substrates
Concentration
Usage And Dosage

 Description

PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis.

For Research Use Only.
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