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L-2-Hydroxyisocaproic Acid Dehydrogenase

 Product Information

Cat #
MBS-2060
CAS No.
81210-65-3
Enzyme Commission Number
EC 1.1.1.337
Product Overview
The product exhibiting the specified enzyme activity, was briefly isolated and purified from genetically modified E. coli. Genetic modifications (e.g. CRISPR/Cas9 System) through gene deletions, allele replacements, and the insertion of new genetic materials have been successfully used to create strains with better fermentation dynamics and stress tolerance.
Features
Ready-to-use product, accelerating research progress, enhancing application performance.
Method
Technology
Synonyms
(R)-sulfolactate:NAD+ oxidoreductase; L-sulfolactate dehydrogenase; (R)-sulfolactate dehydrogenase; L-2-hydroxyacid dehydrogenase (NAD+); ComC
Type
Crude Enzyme
Function
Applications
Research Use
Storage
Store at −20°C or colder.
Storage Buffer
Shelf Life
12 months
Strains
Escherichia coli
Source
Appearance
Solution
Molecular Weight
Color / Form
Instruction
Avoid inhalation during use, prevent contact with skin or mucous membranes, and rinse with water immediately after accidental contact.
Enzyme Class
Oxidoreductases
Production Methods
Recombinant Production
Activity
Undetermined
Specific Enzyme Activity
Purity
Unit Definition
Amino Acids Sequence
WARNINGS
Shipping
Timely shipping by optional means
Formula
Reaction
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+
Recommendation
Molecular biology and biochemistry research tool
Species Reactivity
Contents
Compatibility
Melting Point
Final Titre
Fermentation Time
Recovery Yield
Starting Material
Specification
Standard and Custom Specifications
Substrates
Concentration
Usage And Dosage

 Description

Leucic acid (synonyms of DL-α-hydroxy-isocaproic acid (HICA) and DL-2-hydroxy-4-methylvaleric acid), commonly referred to as its acronym HICA, is a leucine metabolite. Parent leucine is known to be degraded into its primary metabolite which is the keto acid ketoisocaproic acid (called KIC or KICA) and the keto acid tends to exist in equilibrium with leucine. The same enzyme that mediates conversion of leucine to KIC is also required for conversion into HICA, as HICA is a reduction production of KIC via the Hydroxyisocaproic acid dehydrogenase enzyme. Anything that possesses the Hydroxyisocaproic acid dehydrogenase enzyme can produce HICA, and this seems to be humans (mostly in the liver) and select bacteria of the lactobacillus family.

For Research Use Only.
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