Products

Recombinant Kallikrein-1 from Human

Product Information

Cat #

MBS-1085

CAS No.

410538-33-9

Enzyme Commission Number

EC 3.4.21.34

Product Overview

High-quality enzyme products. Well-defined strains can be also provided for our clients to manufacture fermented products in a cost-effective way.

Features

Ready-to-use product, accelerating research progress, enhancing application performance.

Method

Technology

Synonyms

serum kallikrein; kininogenin; kallikrein I; kallikrein II; kininogenase; kallikrein; callicrein; glumorin; padreatin; padutin; kallidinogenase; bradykininogenase; panceatic kallikrein; onokrein P; dilminal D; depot-Padutin; urokallikrein; urinary kallikrein

Type

Function

Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.

Applications

Research Use

Storage

Storage Buffer

Shelf Life

Strains

Pichia Pastoris

Source

Pichia Pastoris

Appearance

Molecular Weight

28-32 kDa

Color / Form

Instruction

Enzyme Class

Hydrolases

Production Methods

Fermentation

Activity

5 Units/mg

Specific Enzyme Activity

Purity

Greater than 98.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Unit Definition

Amino Acids Sequence

WARNINGS

Shipping

Formula

Reaction

Selective cleavage of some Arg┼ and Lys┼ bonds, including Lys┼Arg and Arg┼Ser in (human) kininogen to release bradykinin

Recommendation

Species Reactivity

Contents

Compatibility

Melting Point

Final Titre

Fermentation Time

Recovery Yield

Starting Material

Specification

On customer requests

Substrates

Concentration

Usage And Dosage

Description

Kallikreins are serine protease enzymes having various physiological functions. Kallikreins are implicated in carcinogenesis and have potenital as novel cancer disease biomarkers. KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. Human Kallikrein-1, also called as Kallidinogenase, Kininogenase or Kininogenin, is an active protein enzyme present in saliva, pancreatic juices, and urine that catalyzes the proteolysis of bradykininogen to bradykinin. Kallikrein-1, which derived from human or porcine, have been used as drugs for a long time, they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels.

For Research Use Only.

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